frame-graph02ttt01Overall1.800.20.40.60.811.21.41.6PlaceboXyzalP<0.001Improvement in RQLQQoL_Chart1_All_m[1]OverallPlaceboXyzalP<0.0011.800.20.40.60.811.21.41.6Improvement in RQLQ37%improvementvs placebo (P<0.001)Vector Smart ObjectNasalSymptomsEyeSymptoms**PlaceboXyzal*P<0.001;P<0.051.800.20.40.60.811.21.41.6Improvement in RQLQQoL_Chart1_All_m[1]*P<0.001;P<0.05PlaceboXyzalNasalSymptomsEyeSymptoms**1.800.20.40.60.811.21.41.6Improvement in RQLQVector Smart Object2ActivitiesSleepPracticalProblemsEmotional**PlaceboXyzal*P<0.001;P<0.051.800.20.40.60.811.21.41.6Improvement in RQLQQoL_Chart1_All_m[1]ActivitiesSleepPracticalProblemsEmotional**1.800.20.40.60.811.21.41.6*P<0.001;P<0.05PlaceboXyzalImprovement in RQLQttt02Improvement in WPAI-AS Scores20181614121086420Patient Xperience20181614121086420ctaObject1LevocetirizineXyzalvs.LevocetirizineXyzal 5 mgLevocetirizineDextrocetirizineZyrtec 10 mgvs.Xyzal 5 mgLevocetirizineDextrocetirizineZyrtec 10 mgLevocetirizinesymptom-xpert-graph00-desktop-50-40-30-20-100Xyzal(n=240)Xyzal(n=236)!"!#!$!"#$()*+,-./,01-50-40-30-20-100Percent Reduction in MSCS with XyzalXyzal(n=240)Xyzal(n=236)46%reduction vs 11% placebo (n=93) (P<0.001)34% reduction vs 18% placebo (n=95) (P<0.001)Hour 1Hour 24Week 8Mean T4SS Change from BaselineWeek 10-0.5-1-1.5-2-2.5-3-3.5-4PlaceboXyzalVector Smart Object4PlaceboXyzalWeek 1Week 80-0.5-1-1.5-2-2.5-3-3.5-486%Reductionvs placebo(P<0.001)47%Reductionvs placebo(P<0.001)Mean T4SS Change from Baseline0 -0.5 -1 -1.5 -2 -2.5 -3 -3.5 -4symptom-xpert-graph02-desktopWeek 100.20.40.60.81.06 MonthsMean T5SS Change from BaselineXyzalPlacebo6 MonthsWeek 1PlaceboXyzal00.20.40.60.81.06 MonthsMean T5SS Change from BaselineWeek 16 Months00.20.40.60.81.0PlaceboXyzalMean T5SS Change from BaselineWeek 16 MonthsPlaceboXyzal00.20.40.60.81.0Mean T5SS Change from BaselineWeek 16 MonthsPlaceboXyzal00.20.40.60.81.0Mean T5SS Change from BaselineSignificant Reduction in Symptoms14121086420-2-101 25 26 27 28Mean Score (MSCS)24PlaceboXyzal 5 mg (P<0.001)Hours After Drug IntakeSignificant Reduction in Symptoms

For U.S. Healthcare Professionals Only

Frequently Asked Questions

Q:
What is Xyzal Allergy 24HR?
A:
Xyzal Allergy 24HR is a powerful over-the-counter oral antihistamine used to relieve symptoms associated with indoor and outdoor allergies. When used as directed, it can help temporarily relieve allergy symptoms such as itchy, watery eyes, sneezing and runny nose.1
Q:
How is Xyzal Allergy 24HR different from other antihistamines?
A:
Xyzal Allergy 24HR contains the active enantiomer of Zyrtec® with no dextrocetirizine. This smart formulation offers patients potent medicine for the powerful relief they need.1
Q:
Is over-the-counter Xyzal Allergy 24HR the same strength as the original prescription?
A:
Yes. Xyzal Allergy 24HR and Children’s Xyzal Allergy 24HR are the same, full prescription-strength medicines as their prescription versions.
Q:
Will Xyzal Allergy 24HR make my patients drowsy?
A:
As with most oral antihistamines, Xyzal Allergy 24HR may cause some drowsiness. In clinical studies, 6% of patients taking Xyzal Allergy 24HR experienced drowsiness.1
Q:
How fast does Xyzal Allergy 24HR start working?
A:
Xyzal Allergy 24HR provides noticeable allergy symptom relief in under 1 hour.1,2
Q:
How long does Xyzal Allergy 24HR last?
A:
When used as directed, just one Xyzal Allergy 24HR pill can provide 24-hour relief of allergy symptoms that’s as effective at hour 24 as it is at hour 1.2
Q:
Is Xyzal Allergy 24HR right for my patients?
A:
If your patients need potent relief from allergy symptoms that interfere with sleep, work or school, or day-to-day activities, Xyzal Allergy 24HR may be a wise choice. It offers prescription-strength over-the-counter allergy relief.3
Q:
How much does Xyzal Allergy 24HR cost?
A:
Pricing for Xyzal Allergy 24HR is at the discretion of each retailer. Coupons are available at Xyzal.com and may also be found at the pharmacy counter.
Q:
Is Xyzal Allergy 24HR safe to use for children?
A:
Yes. Children's Xyzal Allergy 24HR has been FDA approved for over-the-counter use in children 2 years of age and older.
Q:
Will insurance cover the cost of Xyzal Allergy 24HR?
A:
Xyzal Allergy 24HR is an over-the-counter (OTC) medicine, and OTC medicines are not typically covered by insurance plans, so be sure to tell patients to check with their insurance provider.
Q:
Does Xyzal Allergy 24HR help with pet or mold allergies?
A:
Yes. Xyzal Allergy 24HR is currently approved for the relief of both indoor and outdoor allergy symptoms, such as pet and mold allergies.
Q:
What sizes of Xyzal Allergy 24HR are available?
A:
Xyzal Allergy 24HR tablets are available in 10 count, 35 count, 55 count, 80 count, and 110 (110 count is only available at club stores). Also, Children’s Xyzal Allergy 24HR is available in a 5 oz. liquid solution.
Q:
Where is Xyzal Allergy 24HR sold without a prescription?
A:
Xyzal Allergy 24HR is available in drug, grocery, mass merchandiser and savings club stores nationwide.

The clinical relevance regarding the absence of dextrocetirizine is unknown.

Footnotes & References
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  • References: 1. Xyzal [prescribing information]. Smyrna, GA: UCB, Inc.; 2016. 2. Horak F, Zieglmayer PU, Zieglmayer R, Kavina A, Lemell P. Levocetirizine has a longer duration of action on improving total nasal symptoms score than fexofenadine after single administration. Br J Clin Pharmacol. 2005;60(1):24-31. 3. Segall N, Gawchik S, Georges G, Haeusler J-MC. Efficacy and safety of levocetirizine in improving symptoms and health-related quality of life in US adults with seasonal allergic rhinitis: a randomized, placebo-controlled study. Ann Allergy Asthma Immunol. 2010;104(3):259-267.